The Adacolumn is a single use direct blood perfusion type apheresis column. Blood can be drawn into the column from the antecubital vein of one hand and returned to the patient via antecubital vein of the contralateral hand, without using a shunt. The commonly used apheresis time has been 60 minutes at 30ml per minute. This is a moderate procedure with minimum burden on patients. The apheresis requires anticoagulant, heparin or nafamostat mesilate.